Mechanochemical Simmons-Smith cyclopropanation via ball-milling-enabled activation of zinc(0)

Abstract

The bulk solvent-free synthesis of cyclopropanes via a ball-milling-enabled Simmons-Smith reaction is herein described. Harnessing the use of mechanochemical techniques to activate zinc(0), this, all under air and operationally simple protocol, allows the synthesis of a wide range of cyclopropane structures and scale up to enable gram-scale.