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In vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii

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Abstract

Background: Sertraline (SRT) is an antidepressant that has proven its activity in vitro against Cryptococcus, Coccidioides, Trichosporon and other fungi. Disseminated sporotrichosis, although rare, has a high mortality and its treatment is difficult and prolonged, often relying in combining two or more antifungals. Aims: In our study we evaluate the antifungal activity of SRT, alone and in combination with itraconazole (ITC), voriconazole (VRC) and amphotericin B (AMB), against 15 clinical isolates of Sporothrix schenckii. Methods: We used the broth microdilution method as described by the CLSI to test the susceptibility to antifungals, and the checkerboard microdilution method to evaluate drug interactions. Results: The minimum inhibitory concentration (MIC) with SRT was in the range of 4–8 μg/ml, while for AMB, VRC and ITC were 0.5–4 μg/ml, 0.5–8 μg/ml and 0.125–2 μg/ml, respectively. In addition, SRT showed synergy with ITC in one strain, mainly additivity with VRC, and indifference with AMB in others. Conclusions: The MIC values with SRT for the isolates studied show the potential role of this drug as an adjuvant in the treatment of sporotrichosis, especially in disseminated or complicated cases.

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Villanueva-Lozano, H., Treviño-Rangel, R. de J., Téllez-Marroquín, R., Bonifaz, A., Rojas, O. C., Hernández-Rodríguez, P. A., & González, G. M. (2019). In vitro inhibitory activity of sertraline against clinical isolates of Sporothrix schenckii. Revista Iberoamericana de Micologia, 36(3), 139–141. https://doi.org/10.1016/j.riam.2019.01.004

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