Oxidative stress and inflammatory markers in normal pregnancy and preeclampsia

Abstract

Aim: Although previous investigators have demonstrated the presence of oxidative stress and inflammation in preeclampsia, none directly correlate both to preeclampsia. Methods: We determined in 35 preeclamptic and 35 normotensive pregnant women plasma levels of thiobarbituric acid reactive species, protein carbonyl, tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6 and IL-10. Results: Plasma thiobarbituric acid reactive species and protein carbonyls were higher in preeclamptic patients. TNF-α and IL-6 (but not IL-1β or IL-10) were higher in preeclamptic patients. We found significant correlation between plasma IL-6 and carbonyls, and these correlated to blood pressure. Conclusions: We demonstrated that some oxidative and inflammatory mediators were altered in preeclampsia, and some correlated to blood pressure. © 2008 Japan Society of Obstetrics and Gynecology.