Time History of Human Gallstones: Application of the Post-Bomb Radiocarbon Signal

Abstract

Bomb-produced 14 C is a valuable tool for studying rates of short-term processes involving carbon cycling. This study shows that bomb 14 C is an excellent tracer of a biochemical process that takes place in the human body, namely the accretion of stones in the gallbladder. The methods developed for obtaining time histories of 14 C/ 12 C and 13 C/ 12 C in concentric layers from a large gallstone (30mm diameter) are reported. Formation times are assigned by matching the 14 C/ 12 C obtained from individual layers with those found for known-aged tree rings. Results show that the gallstone grew over a period of 10 years and seems to have lain dormant within the gallbladder for a period of 11 years. The average growth rate was 1.5mm/year.