The cell ultrastructure and some detoxifying enzyme activities were studied in skeletal muscles of young rats kept for 84 h under normobaric hyperoxia (95% O2) or normoxia as control. Rat were injected ip. Every 12 h either with 1ml saline, 1 ml saline+30 mg hypotaurine or 1 ml saline+30 mg taurine. Ultrastructural observation revealed an highly protective effect on tissue damages due to hyperoxia in taurine-treated rats and, at less extent, in hypotaurine-treated ones. Enzymatic assays suggest a different mechanism of the two molecules in their protective action.
CITATION STYLE
Pitari, G., Duprè, S., Ragnelli, A. M., Aimola, P., Di Giulio, C., & Amicarelli, F. (2000). Biochemical and ultrastructural alterations in rat after hyperoxic treatment: Effect of taurine and hypotaurine. Advances in Experimental Medicine and Biology, 483, 149–156. https://doi.org/10.1007/0-306-46838-7_15
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