Discovery of α-Klotho unveiled new insights into calcium and phosphate homeostasis

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Abstract

α-Klotho was first identified as the responsible gene in a mutant mouse line whose disruption results in a variety of premature aging-related phenotypes. α-Klotho has been shown to participate in the regulation of parathyroid hormone secretion and trans-epithelial transport of Ca2+ in the choroid plexus and kidney. α-Klotho, acting as a cofactor for FGF23, is also a major regulator of vitamin D biosynthesis and phosphate reabsorption in the kidney. These suggest that α-Klotho is a key player that integrates a multi-step regulatory system of calcium and phosphate homeostasis. Collectively, the molecular function of α-Klotho reveals a new paradigm that may change current concepts in mineral homeostasis and give rise to new insights in this field. © 2009 The Japan Academy.

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Nabeshima, Y. ichi. (2009, March). Discovery of α-Klotho unveiled new insights into calcium and phosphate homeostasis. Proceedings of the Japan Academy Series B: Physical and Biological Sciences. https://doi.org/10.2183/pjab.85.125

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