Integrating prior knowledge of pathway-level information can enhance power and facilitate interpretation of gene expression data analyses. Here, we provide a practical demonstration of the value of gene set or pathway enrichment testing and extend such techniques to identify and characterize transcriptional subpopulations from single-cell RNA-sequencing data using pathway and gene set overdispersion analysis (PAGODA).
CITATION STYLE
Fan, J. (2019). Differential pathway analysis. In Methods in Molecular Biology (Vol. 1935, pp. 97–114). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9057-3_7
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