It has recently been proposed that in rat models of genetic hypertension, supplemental dietary potassium preserves release of endothelium-derived relaxing factor independently of its capacity to either attenuate hypertension or increase plasma potassium. To test this hypothesis in Dahl salt-sensitive rats given sodium chloride (4%) for 3 weeks, we supplemented dietary potassium (2.1%) with either KCl (n=16) or KHCO3 (n=16). Compared with unsupplemented rats (n=16), rats supplemented with either potassium salt had a lower mean arterial pressure and a greater release of endothelium-derived relaxing factor, as assessed from acetylcholine-induced relaxation of precontracted aortic rings. However, the maximum relaxation response to acetylcholine correlated inversely with blood pressure (r=-.82, P <001) groups but also in unsupplemented rats (r=-,86, P
CITATION STYLE
Sudhir, K., Kurtz, T. W., Yock, P. G., Connolly, A. J., & Morris, R. C. (1993). Potassium preserves endothelial function and enhances aortic compliance in Dahl rats. Hypertension, 22(3), 315–322. https://doi.org/10.1161/01.hyp.22.3.315
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