GC–MS profiling and antibacterial activity of Solanum khasianum leaf and root extracts

Abstract

Background: Solanum khasianum is an important medicinal herb of the Solanaceae family. The present study was focused to determine the bioactive compounds in S. khasianum leaf and root extract by GC-MS analysis and their antibacterial activity by agar well diffusion method. Results: Sixteen bioactive compounds were detected in leaf extract and thirty-two compounds in root methanolic extract by GC-MS. The major potent compounds identified in leaf and root extracts were heptadecane 9-hexyl (43.65%) and stigmasterol (23.18%). The root extract showed increased antibacterial activity than leaf extract. Conclusion: These extracts possessed significant antibacterial activity against the tested bacterial isolates in dose-dependent manner. This study provides the phytoconstituents, antibacterial property and scientific evidence for the traditional claim and use of S. khasianum.