Mechanisms of liver injury

Abstract

A diverse range of pathophysiologic processes lead to liver injury in the pediatric population. This chapter discusses mechanisms of hepatocyte or other liver cellular injury, beginning with a brief discussion of liver functions and general mechanisms of cell death. Particular attention is paid to the role of apoptotic pathways and mitochondrial damage in liver diseases, including metabolic disorders, infections, toxin ingestions, and diseases that primarily affect the biliary tree.