Endosomal integrin signals for survival

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Abstract

The mechanisms underlying integrin-dependent signalling are a topic of continued study. Endocytosed integrins are now shown to drive assembly of signalling complexes on the cytoplasmic face of endocytic membranes to promote cancer cell survival and increase metastatic capacity following cell detachment.

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Rainero, E., & Norman, J. C. (2015). Endosomal integrin signals for survival. Nature Cell Biology, 17(11), 1373–1375. https://doi.org/10.1038/ncb3261

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