Two novel serotype-specific HLA-A*0201-restricted CD8(+) T-cell epitopes (NS4a(140-148) and NS2a(144-152)) and one cross-reactive HLA-A*0201-restricted CD8(+) T-cell epitopes which is similar to a previously identified epitope were identified in D1V-D4V. Combining prediction algorithms and HLA transgenic mice is an effective strategy to identify HLA-restricted epitopes. Serotype-specific epitopes would be used to determine the protective role of serotype-specific CD8(+) T cells, while cross-reactive epitopes may provide assistance in exploring the role of serotype cross-reactive CD8(+) T cells in the immunopathogenesis of DHF/DSS.
CITATION STYLE
Gagarin, A., Kevorkov, D., Makarenkov, V., & Zentilli, P. (2006). Comparison of Two Methods for Detecting and Correcting Systematic Error in High-throughput Screening Data. In Data Science and Classification (pp. 241–249). Springer Berlin Heidelberg. https://doi.org/10.1007/3-540-34416-0_26
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