Mechanisms of ovarian cancer metastasis: Biochemical pathways

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Abstract

Ovarian cancer is the most lethal gynecologic malignancy. Despite advances in chemotherapy, the five-year survival rate of advanced ovarian cancer patients with peritoneal metastasis remains around 30%. The most significant prognostic factor is stage, and most patients present at an advanced stage with peritoneal dissemination. There is often no clearly identifiable precursor lesion; therefore, the events leading to metastatic disease are poorly understood. This article reviews metastatic suppressor genes, the epithelial-mesenchymal transition (EMT), and the tumor microenvironment as they relate to ovarian cancer metastasis. Additionally, novel chemotherapeutic agents targeting the metastasis-related biochemical pathways are discussed. © 2012 by the authors; licensee MDPI, Basel, Switzerland.

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Nakayama, K., Nakayama, N., Katagiri, H., & Miyazaki, K. (2012). Mechanisms of ovarian cancer metastasis: Biochemical pathways. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms130911705

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