Abstract
The 6,7-dihydroxycoumarin-5-carboxylates DHCou and 4-Me-DHCou have been synthesized via five-step route including a propargyl-Claisen rearrangement as key step. The compounds show antibiofilm activity against Stapylococcus aureus and Candida albicans but lack the cytotoxic activity of parent 6,7-dihydroxycoumarines such as esculetin and 4-methylesculetin.
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CITATION STYLE
Zscherp, R., Chakrabarti, A., Lehmann, A. P., Schrey, H., Zeng, H., Collisi, W., & Klahn, P. (2023). Design of non-cytotoxic 6,7-dihydroxycoumarin-5-carboxylates with antibiofilm activity against Staphylococcus aureus and Candida albicans. Organic and Biomolecular Chemistry, 21(23), 4744–4749. https://doi.org/10.1039/d3ob00303e
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