Nanotherapy Targeting NF-kB Attenuates Acute Pain After Joint Injury

Abstract

Inflammation after joint injury leads to responses that result in eventual osteoarthritis development. Blockade of inflammation, by suppressing NF-kB expression, has been shown to reduce joint injury-induced chondrocyte apoptosis and reactive synovitis in vivo. Herein, we demonstrate that the suppression of NF-kB p65 expression also significantly mitigates the acute pain sensitivity induced by mechanical injury to the joint. These results suggest that early intervention with anti-NF-KB nanotherapy mitigates both structural and pain-related outcomes, which in turn may impact the progr ession of post-traumatic osteoarthr itis.