Controlled Release of Doxofylline from Biopolymer Based Hydrogels

Abstract

AbstractIn order to modify the xanthan gum (XG) polysaccharide and to develop the hydrogels meant for the drug delivery, we have prepared XG-g-poly [HEMA-co-AA] superporous hydrogel (SPH) through chemical cross-linking by graft copolymerization of 2-hydroxyethyl methacrylate (HEMA) and acrylic acid (AA) on to XG via redox initiator system of ammonium persulfate (APS) and N, N, N', N'-tetramethylethylenediamine (TMED), in the presence of N, N'-methylenebisacrylamide (MBA) crosslinking agent, sodium bicarbonate foaming agent, a triblock copolymer of polyoxyethylene/ polyoxypropylene/ polyoxyethylene as a foam stabilizer. Characterization of SPH was done by FT-IR, TGA, SEM, HPLC and GCMS. The prepared SPH were successfully loaded with Doxofylline (DF) drug and formulation H 10 showed higher % drug content (98±2.3) and % drug entrapment efficiency (83±2.0). From the in Vitro drug release study in pH progressive media, formulation H 10 showed comparatively higher release extending upto 24h.The mechanism of DF release from the SPH matrix was found to be of diffusion type.