A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR- and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo- and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time.
CITATION STYLE
Bogdanov, A., Tsivileva, O., Voloshina, A., Lyubina, A., Amerhanova, S., Burtceva, E., … Pavlov, V. (2022). Synthesis and diverse biological activity profile of triethyl-ammonium isatin-3-hydrazones. ADMET and DMPK, 10(2), 163–179. https://doi.org/10.5599/admet.1179
Mendeley helps you to discover research relevant for your work.