Synthesis and diverse biological activity profile of triethyl-ammonium isatin-3-hydrazones

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Abstract

A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR- and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo- and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time.

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Bogdanov, A., Tsivileva, O., Voloshina, A., Lyubina, A., Amerhanova, S., Burtceva, E., … Pavlov, V. (2022). Synthesis and diverse biological activity profile of triethyl-ammonium isatin-3-hydrazones. ADMET and DMPK, 10(2), 163–179. https://doi.org/10.5599/admet.1179

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