Entosis is a mechanism of cell competition occurring in cancers that involves the engulfment and killing of neighboring cells. The death of ingested cells, called entotic cell death, usually occurs in a non-apoptotic, autophagy protein-dependent manner, where microtubule-associated protein light chain 3 (LC3) is lipidated onto entotic vacuoles. Here we present methods to quantify entotic cell death and its associated LC3 lipidation.
CITATION STYLE
Hamann, J. C., Kim, S. E., & Overholtzer, M. (2019). Methods for the study of entotic cell death. In Methods in Molecular Biology (Vol. 1880, pp. 447–454). Humana Press Inc. https://doi.org/10.1007/978-1-4939-8873-0_28
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