A Novel 16,23-Epoxy-5β-Cholestane Glycoside with Potent Inhibitory Activity on Proliferation of Human Peripheral Blood Lymphocytes from Ornithogalum Saundersiae Bulbs

Abstract

A novel 16,23-epoxy-5β-cholestane triglycoside (1) was isolated from the bulbs of Ornithogalum saundersiae (Liliaceae). The structure was determined by extensive spectroscopic analysis. The conformation of the E-ring part of 1 was studied through molecular mechanics and molecular dynamics calculation methods. Compound 1 potently inhibited proliferation of peripheral blood lymphocytes provided from a chronic renal failure patient without causing any cytotoxicity in the lymphocytes and HL-60 human leukemia cells. © 1995, The Pharmaceutical Society of Japan. All rights reserved.