Paradigm Shift in Metastatic Malignant Melanoma

Abstract

Substantial advancements have been made in the treatment of metastatic malignant melanoma, for which therapeutic options were quite limited until recently, with the elucidation of molecular pathways that play role in the development and progression of the disease. Although remarkable improvement has been achieved in survival rates with these advancements, a satisfactory response rate could not be obtained or high response rates could not be maintained. In this paper, therapeutic options for metastatic melanoma, particularly ipilimumab and vemurafenib that are also in use in our country, were summarized.