Synthetics Methods for the Preparation of Biaryls

Abstract

The biaryl structural unit is often found in natural products, drugs and agrochemicals. Therefore, the formation of the carbon-carbon bond is of extreme importance in the synthetic planning of substances. Many methods of obtaining biaryls are described in the literature, however, nickel or palladium catalyzed cross-coupling methodologies, such as Kuma-Tamao-Corriu, Negishi, Migita-Kosug-Stille, Suzuki-Miyaura and Hiyama are the most important and most used tools today. These reactions avoid the need for protection and deprotection of functional groups, as they are tolerant to most groups, such as: Aldehydes, ketones, amino, nitriles, hydroxides, esters and nitro group. In this work, these cross-coupling methodologies and their main characteristics will be discuss.