Clinical and experimental study of shuangcao tuihuang granule-1 in treating severe jaundice of acute icterohepatitis

Abstract

OBJECTIVE: To observe the effect of Shuangcao Tuihuang Granule-1 (SCTH-1) in treating severe jaundice of acute icterohepatitis and to study its mechanism. METHODS: Thirty-four patients with severe jaundice of acute icterohepatitis were treated with SCTH-1, their therapeutic effects were analyzed. In the experimental studies, the influences of SCTH-1 on acute liver injury, liver superoxide dismutase (SOD) and serum ALT and AST were monitored. RESULTS: The markedly effective rate and effective rate of the treated group were 73.5% and 23.5% respectively. The markedly effective rate of the treated group was obviously higher than that of the control group (P < 0.05). Experimental study revealed that SCTH-1 could reduce the level of serum transaminase and inflammation of liver tissue in mice with acute liver damage. In addition, SCTH-1 could raise the activity of liver SOD (P < 0.05). CONCLUSION: SCTH-1 could accelerate the jaundice subsidence, improve the liver function and ameliorate the liver injury, its mechanism was possibly correlated with raising SOD activity, scavenging the oxygen free radicals.