Synthesis and Antibacterial Study of Aspirin-Chalcone Derivatives

Abstract

The chemistry of aspirin and chalcone derivatives has been extensively studied and developed as one of thepharmaceutically important molecules. In this study, new aspirin-chalcone derivatives have been successfullysynthesized and characterized via FTIR, 1H and 13C NMR spectroscopy. The antibacterial activities ofsynthesized compounds were investigated towards Escherichia coli ATCC 8739 via turbidimetric kineticmethod. The newly synthesized aspirin-chalcone derivatives, however showed poor antibacterial activityagainst E. coli ATCC 8739 at the concentration of 50, 80 and 100 ppm. The effect of the molecular structureof the synthesized compounds on the antibacterial activity is discussed.