Dose response on the faecal colonisation of lactobacillus strain GG administered in two different formulations

Abstract

Faecal concentrations of Lactobacillus GG in human subjects were studied after oral administration of the bacterium Lactobacillus GG was given in total to 44 healthy human volunteers for 7 d as enterocoated tablets with daily doses of 1 × 109c.f.u.,4x 109and 8 × 109 c.f.u. and in fermented milk with daily doses of 21 × 109c.f.u. and 1.2 × 1010 c.f.u. All the volunteers excreted the organism by day 3 of the test period. There were no statistical differences in mean faecal Lactobacillus GG contents between the tablet groups. With fermented milk there was a clear, statistically significant increase in mean faecal Lactobacillus GG content when the administration was l.2x 1010 c.f.u./d compared to 21 × 109 c.f.u./d. The results indicate that fermented milk and enterocoated tablets are good carriers for administering Lactobacillus GG as a probiotic organism. © 1993 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.