Establishment of Age Specific Reference Range of Serum PSA Level among Healthy Indian Hindu and Muslim Males

Abstract

Aim: This study was aimed to investigate the racial and ethnic differences in age specific references range of serum Prostate Specific Antigen (PSA) among healthy Indian Hindu and Muslim males and its comparison with Asian population. Method: The present study was done at Medanta-The Medicity on 1300 adult Indian male patients who were visiting in the executive health checkup package. Out of 1300 subjects, 1060 healthy subjects were Hindus and 193 were Muslims without any prostate disease ranging from age 19-97 years, while rest 47 were excluded due to some urological diseases. Statistical analysis was carried out. Mean + SD, median and the central 95 percentile were calculated for each age group. Result: The age specific reference range of serum PSA values in healthy Hindu males is 0.69 ng/ml in those younger than 40 years; 0.83 ng/ml in 40-49 years; 1.13 ng/ml in 50-59 yrs group; 1.46 ng/ml in 60-69 yrs group; 1.83 ng/ml in men's older than 70 years age group. Whereas the age specific reference range of serum PSA values in healthy Muslim males is 0.86 in those younger than 40 years; 1.01 ng/ml in 40-49 years; 1.41 ng/ml in 50-59 yrs group; 1.70 ng/ml in 60-69 yrs group; 2.92 ng/ml in men's older than 70 years age group. Conclusion: Present study highlighted the age-specific reference range of serum PSA in Healthy Hindu Males are on lower side as compared to Muslim males. The data also suggested that the PSA levels are associated with increasing age.