Adaptation to Resource Availability as a Determinant of Chemical Defense Strategies in Woody Plants

Abstract

Poly(norbornene) supports comprising solubilizing ethylene glycol units andmultiple amino acid attachment sites have been developed for peptide synthesis.Avariety of amino acids have been efficiently loaded (0.6?1.1mmol/g) onto the support in high yields (83?98%). Several tripeptides have been synthesized in moderate-to-good overall yields (41?66%) using only 1.2 equiv of coupling reagents/amino acids, and the support could be efficiently recycled up to 3 times.