With imatinib still being linked to the breakthrough in CML therapy and probably being the most prescribed drug, second-generation TKIs are increasingly gaining importance. Showing higher response rates while not leading to more adverse events, nilotinib has become an attractive option in the first-line treatment of chronic-phase chronic myeloid leukemia. By reaching deep and long-lasting molecular remissions, discontinuation of TKIs is becoming one of the central topics of future CML therapy. Stopping nilotinib seems safe and provides a stable remission in about half of the eligible patients, though long-term data are still missing.
CITATION STYLE
Gresse, M., Kim, T. D., & Le Coutre, P. (2018). Nilotinib. In Recent Results in Cancer Research (Vol. 212, pp. 69–85). Springer New York LLC. https://doi.org/10.1007/978-3-319-91439-8_3
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