Development of Opthalmic Formulation for Dry Eye Syndrome

Abstract

Volume 3 • Issue 4 • 1000166 Adv Pharmacoepidemiol Drug Saf ISSN: 2167-1052 APDS, an open access journal Eye drops are sterile, aqueous or oily solutions or oil solutions or suspensions of one or more medicaments intended for instillation into the conjunctival sac. They may contain suitable auxiliary substances such as buffers, stabilizing agents, solubilizing agents and agents to adjust the tonicity or viscosity of the preparation. Unlike creams and ointments, these systems have obvious advantages such as ease of administration, ease of mixing with tear fluid and ability to spread over the corneal surface. Increased viscosity of the instilled drops improves contact time of drug with the site of application and can provide better therapeutic efficacy unlike eye solutions, which drain out rapidly from the eyes. In present study, the objective was to prepare ophthalmic drops using suitable concentration of acacia gum that enhances the contact time and also leaves a thin film of drug over the eye surface. Various concentrations of acacia were analyzed to find the suitable concentration for stability of formulation. Viscosity increases the contact time of the formulation. An ophthalmic formulation is provided for the prevention and treatment of adverse ocular conditions, including presbyopia, arcus senilis, age-related macular degeneration, and other conditions associated with aging. In present study, the objective was to prepare ophthalmic drops using suitable concentration of acacia gum that enhances the contact time and also leaves a thin film of drug over the eye surface. Various concentrations of acacia were analyzed to find the suitable concentration for stability of formulation. Viscosity increases the contact time of the formulation. An ophthalmic formulation is provided for the prevention and treatment of adverse ocular conditions, including presbyopia, arcus senilis, age-related macular degeneration, and other conditions associated with aging. Too much viscosity produces irritation in eye, hence optimal viscosity was achieved. Viscosity measurements were done using Oswald viscometer and Brookfield viscometer. Apart from providing viscosity to the ophthalmic solutions acacia is also a natural source of calcium and magnesium. These are essential nutrients to eye.