Paligenosis: prepare to regenerate!

  • Messal H
  • Cremona C
  • Lan L
  • et al.
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Abstract

Tissue injury can stimulate quiescent cells to proliferate, resulting in metaplasia, to rapidly replace damaged cells and enable regeneration. A new study describes how fully differentiated cells return to proliferation in an autophagy‐ and mTORC1‐dependent manner. Given the striking parallels between this process in mammalian stomach and pancreas, a new term, paligenosis, is proposed for this conserved program. The EMBO Journal (2018) 37: e99206

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Messal, H. A., Cremona, C. A., Lan, L., & Behrens, A. (2018). Paligenosis: prepare to regenerate! The EMBO Journal, 37(7). https://doi.org/10.15252/embj.201899206

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