Roles of transposable elements in the different layers of gene expression regulation

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Abstract

The biology of transposable elements (TEs) is a fascinating and complex field of investigation. TEs represent a substantial fraction of many eukaryotic genomes and can influence many aspects of DNA function that range from the evolution of genetic information to duplication, stability, and gene expression. Their ability to move inside the genome has been largely recognized as a double-edged sword, as both useful and deleterious effects can result. A fundamental role has been played by the evolution of the molecular processes needed to properly control the expression of TEs. Today, we are far removed from the original reductive vision of TEs as “junk DNA”, and are more convinced that TEs represent an essential element in the regulation of gene expression. In this review, we summarize some of the more recent findings, mainly in the animal kingdom, concerning the active roles that TEs play at every level of gene expression regulation, including chromatin modification, splicing, and protein translation.

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Drongitis, D., Aniello, F., Fucci, L., & Donizetti, A. (2019, November 2). Roles of transposable elements in the different layers of gene expression regulation. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms20225755

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