Biomaterial-Based Vectors for Targeted Delivery of Nucleic Acids to the Nervous System

Abstract

One of the challenges currently facing neuroscientists is the development of effective therapies based on the advances achieved on basic research. The use of genes as pro-drugs can be faced as an approach to reduce this gap. Furthermore, gene downregulation through the use of antisense strategies, including the recent introduction of RNA interference, is yet another tool with great therapeutic potential.