RNAs as Sensors of Oxidative Stress in Bacteria

10Citations
Citations of this article
34Readers
Mendeley users who have this article in their library.

Abstract

Oxidative stress is an important and pervasive physical stress encountered by all kingdoms of life, including bacteria. In this review, we briefly describe the nature of oxidative stress, highlight well-characterized protein-based sensors (transcription factors) of reactive oxygen species that serve as standards for molecular sensors in oxidative stress, and describe molecular studies that have explored the potential of direct RNA sensitivity to oxidative stress. Finally, we describe the gaps in knowledge of RNA sensors-particularly regarding the chemical modification of RNA nucleobases. RNA sensors are poised to emerge as an essential layer of understanding and regulating dynamic biological pathways in oxidative stress responses in bacteria and, thus, also represent an important frontier of synthetic biology.

Cite

CITATION STYLE

APA

Buchser, R., Sweet, P., Anantharaman, A., & Contreras, L. (2023, June 8). RNAs as Sensors of Oxidative Stress in Bacteria. Annual Review of Chemical and Biomolecular Engineering. Annual Reviews Inc. https://doi.org/10.1146/annurev-chembioeng-101121-070250

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free