Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coro-navirus 2 (SARS-CoV-2), a novel coronavirus in humans, has expanded globally over the past year. COVID-19 remains an important subject of intensive research owing to its huge impact on economic and public health globally. Based on historical archives, the first coronavirus-related disease rec-orded was possibly animal-related, a case of feline infectious peritonitis described as early as 1912. Despite over a century of documented coronaviruses in animals, the global animal industry still suffers from outbreaks. Knowledge and experience handling animal coronaviruses provide a valuable tool to complement our understanding of the ongoing COVID-19 pandemic. In this review, we present an overview of coronaviruses, clinical signs, COVID-19 in animals, genome organization and recombination, immunopathogenesis, transmission, viral shedding, diagnosis, treatment, and prevention. By drawing parallels between COVID-19 in animals and humans, we provide perspectives on the pathophysiological mechanisms by which coronaviruses cause diseases in both animals and humans, providing a critical basis for the development of effective vaccines and therapeutics against these deadly viruses.
CITATION STYLE
Lin, C. N., Chan, K. R., Ooi, E. E., Chiou, M. T., Hoang, M., Hsueh, P. R., & Ooi, P. T. (2021, August 1). Animal coronavirus diseases: Parallels with COVID-19 in humans. Viruses. MDPI AG. https://doi.org/10.3390/v13081507
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