Adhesion G Protein-coupled Receptors - Molecular, Physiological and Pharmacological Principles in Health and Disease

Abstract

"Latest research on adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them into metabotropic signals through the action of a novel activation paradigm. Interdisciplinary efforts transcending many areas of biomedical research including pharmacology, physiology, genetics, cell biology, structural biology, biochemistry and bioinformatics were necessary to unveil these fundamental properties. The scientific leaders in the field that carried this research effort have teamed up here to provide a comprehensive overview of our current understanding, how adhesion GPCRs signal and how these receptors shape organ structure and function"--Publisher's description. Introduction: history of the adhesion GPCR field / J̲örg Hamann, Alexander G. Petrenko -- Molecular and pharmacological properties of adhesion GPCRs. Classification, nomenclature, and structural aspects of adhesion GPCRs / Arunkumar Krishnan, Saskia Nijmeijer, Chris de Graaf, Helgi B. Schi̲th -- 7TM domain structure of adhesion GPCRs / Chris de Graaf, Saskia Nijmeijer, Steffen Wolf, Oliver P. Ernst -- Understanding the structural basis of adhesion GPCR functions / Demet Araç, Norbert Sträter, Elena Seiradake -- Control of adhesion GPCR function through proteolytic processing / Matthias Nieberler, Robert J. Kittel, Alexander G. Petrenko, Hsi-Hsien Lin [and others] -- Tethered agonism: a common activation mechanism of adhesion GPCRs / Ines Liebscher, Torsten Sch̲öneberg -- Versatile signaling activity of adhesion GPCRs / Ayush Kishore, Randy A. Hall -- Adhesion GPCR-related protein networks / Barbara Knapp, Uwe Wolfrum -- The relevance of genomic signatures at adhesion GPCR loci in humans / Peter Kovacs, Torsten Sch̲öneberg -- Adhesion GPCRs as pharmakotargets in organ function and development. Adhesion GPCRs as a putative class of metabotropic mechanosensors / Nicole Scholz, Kelly R. Monk, Robert J. Kittel, Tobias Langenhan -- Adhesion GPCRs govern polarity of epithelia and cell migration / David Strutt, Ralf Schnabel, Franziska Fiedler, Simone Pr̲mel -- Adhesion GPCRs as novel actors in neural and glial cell functions: from synaptogenesis to myelination / Séverine M. Sigoillot, Kelly R. Monk, Xianhua Piao, Fekrije Selimi, Breanne L. Harty -- Control of skeletal muscle cell growth and size through adhesion GPCRs / James P. White -- Adhesion GPCR function in pulmonary development and disease / Marie-Gabrielle Ludwig, Klaus Seuwen, James P. Bridges -- Adhesion GPCRs as modulators of immune cell function / J̲örg Hamann, Cheng-Chih Hsiao, Chang Sup Lee, Kodi S. Ravichandran, Hsi-Hsien Lin -- Heart development, angiogenesis, and blood-brain barrier function is modulated by adhesion GPCRs / Gentian Musa, Felix B. Engel, Colin Niaudet -- Adhesion GPCRs in tumorigenesis / Gabriela Aust, Dan Zhu, Erwin G. Van Meir, Lei Xu.