Role of gamma-delta ( γδ ) T cells in autoimmunity

Abstract

© Society for Leukocyte Biology.γδT cells represent a small population of overall T lymphocytes (0.5–5%) and have variable tissue distribution in the body. γδT cells can perform complex functions, such as immune surveillance, immunoregulation, and effector function, without undergoing clonal expansion. Heterogeneous distribution and anatomic localization of γδT cells in the normal and inflamed tissues play an important role in alloimmunity, autoimmunity, or immunity. The cross-talk between γδT cells and other immune cells and phenotypic and functional plasticity of γδT cells have been given recent attention in the field of immunology. In this review, we discussed the cellular and molecular interaction of γδT cells with other immune cells and its mechanism in the pathogenesis of various autoimmune diseases.