Efeito do uso de broncodilatadores nas propriedades resistivas e reativas do sistema respiratório de indivíduos saudáveis e com doença pulmonar obstrutiva crônica

Abstract

In Chronic Obstructive Pulmonary Disease (COPD) the response to inhaled bronchodilators by means of spirometry is controversial. The objective of this study was to determine the effect acute of salbutamol on the resistive and reactive properties of the respiratory system in COPD patients. A total of 38 subjects were analyzed, 10 healthy control e 28 with COPD, We used the forced oscillation technique (FOT) before and after inhalation of 300 ug salbutamol. Impedance data were interpreted using the total respiratory system resistance (R0); the dynamic compliance (Cdyn); and the slope of the resistance (S), both of which are associated with the homogeneity of the respiratory system. All groups show significant differences between the prebronchodilator and postbronchodilator, except of the healthy subjects in FOT parameters. Values of p < 0.001 were obtained for R0 and S in comparisons between all groups. In all groups Δ%R0, Δ%S e Δ%Cdin was inversely related with the classification of the disease. We conclude that the use of salbutamol improved the resistive properties of the respiratory system of COPD patients proportionally to the degree of airway obstruction. The FOT provide parameters that could be helpful in the analysis of bronchodilation in COPD. © 2013 Springer.