Cytokines are a heterogeneous group of soluble small polypeptides or glycoproteins, which exert pleiotropic and redundant effects that promote growth, differentiation and activation of normal cells. Cytokines can have either pro- or anti-inflammatory activity and immunosuppressive activity, depending on the microenvironments. The tumor microenvironment consists of a variable combination of tumor cells, endothelial cells and infiltrating leukocytes, such as macrophages, T-lymphocytes, natural killer (NK) cells, B cells and antigen-presenting cells (APCs). Cytokine production acts as a means of communication in the tumor microenvironment. In this article, we review the cross-talk between cytokines in the tumor environment and the cytokine therapies that have been used till date for glioma treatment. © 2012 Landes Bioscience and Springer Science+Business Media.
CITATION STYLE
Ohno, M., Natsume, A., & Wakabayashi, T. (2012). Cytokine therapy. Advances in Experimental Medicine and Biology, 746, 86–94. https://doi.org/10.1007/978-1-4614-3146-6_7
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