Abstract
Background: The process of matrix degradation is an integral component of cell invasion. Results: Actopaxin phosphorylation is required for matrix degradation. Conclusion: Actopaxin can act upstream of Rho GTPase signaling via an interaction with β-PIX and PAK to control matrix degradation. Significance: Matrix degradation is a pivotal step in cell invasion and cancer cell metastasis. © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Pignatelli, J., LaLonde, S. E., LaLonde, D. P., Clarke, D., & Turner, C. E. (2012). Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion. Journal of Biological Chemistry, 287(44), 37309–37320. https://doi.org/10.1074/jbc.M112.385229
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