Design Parameters of Tissue-Engineering Scaffolds at the Atomic Scale

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Abstract

Stem-cell behavior is regulated by the material properties of the surrounding extracellular matrix, which has important implications for the design of tissue-engineering scaffolds. However, our understanding of the material properties of stem-cell scaffolds is limited to nanoscopic-to-macroscopic length scales. Herein, a solid-state NMR approach is presented that provides atomic-scale information on complex stem-cell substrates at near physiological conditions and at natural isotope abundance. Using self-assembled peptidic scaffolds designed for nervous-tissue regeneration, we show at atomic scale how scaffold-assembly degree, mechanics, and homogeneity correlate with favorable stem cell behavior. Integration of solid-state NMR data with molecular dynamics simulations reveals a highly ordered fibrillar structure as the most favorable stem-cell scaffold. This could improve the design of tissue-engineering scaffolds and other self-assembled biomaterials.

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Jekhmane, S., Prachar, M., Pugliese, R., Fontana, F., Medeiros-Silva, J., Gelain, F., & Weingarth, M. (2019). Design Parameters of Tissue-Engineering Scaffolds at the Atomic Scale. Angewandte Chemie - International Edition, 58(47), 16943–16951. https://doi.org/10.1002/anie.201907880

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