SNAREs: Could they be the answer to an energy landscape riddle in exocytosis?

15Citations
Citations of this article
21Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

During exocytosis, chemical transmitters stored in secretory vesicles can be released upon fusion of these intracellular organelles to the plasma membrane. In this process, SNARE proteins that form a ternary core complex play a central role. This complex could provide the means for generation/storage of energy necessary for driving the fusion of vesicular and plasma membranes. Recently, the amount of energy for (dis)assembly of the ternary complex has been measured using various experimental approaches, including atomic force microscopy, the surface force apparatus, and isothermal titration calorimetry. The obtained measurements are in good agreement with the calculated energy required for membrane fusion achieved by theoretical modeling approaches. Whether the energy expenditure to form the ternary SNARE complex can be utilized towards membrane fusion and/or docking/tethering of vesicles to the plasma membrane still remains one of the key contemporary issues in biophysics and neuroscience. ©2010 with author.

References Powered by Scopus

SNAP receptors implicated in vesicle targeting and fusion

2811Citations
N/AReaders
Get full text

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

2004Citations
N/AReaders
Get full text

Membrane fusion: Grappling with SNARE and SM proteins

1643Citations
N/AReaders
Get full text

Cited by Powered by Scopus

The Synaptic Vesicle Release Machinery

268Citations
N/AReaders
Get full text

Applications of isothermal titration calorimetry in pure and applied research-survey of the literature from 2010

160Citations
N/AReaders
Get full text

Different Infectivity of HIV-1 Strains Is Linked to Number of Envelope Trimers Required for Entry

72Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Liu, W., & Parpura, V. (2010, June 29). SNAREs: Could they be the answer to an energy landscape riddle in exocytosis? TheScientificWorldJournal. https://doi.org/10.1100/tsw.2010.137

Readers over time

‘11‘12‘13‘15‘16‘17‘18‘19‘20‘21‘2202468

Readers' Seniority

Tooltip

Researcher 7

37%

Professor / Associate Prof. 6

32%

PhD / Post grad / Masters / Doc 6

32%

Readers' Discipline

Tooltip

Agricultural and Biological Sciences 8

50%

Biochemistry, Genetics and Molecular Bi... 5

31%

Physics and Astronomy 2

13%

Neuroscience 1

6%

Save time finding and organizing research with Mendeley

Sign up for free
0