Thiamine Is a Precursor of DNA Strand Breakage and Mutagenic Substance (s) When Mixed with Nitrite

2Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

DNA strand breakage activity and mutagenicity of the product (s) formed by a reaction of thiamine and nitrite under simulated gastric conditions were examined. A reaction mixture of thiamine and nitrite at pH 3 induced DNA single-strand breaks when incubated with a supercoiled Plasmid DNA at pH 7.4 and 37°C. Product (s) from thiamine and nitrite were found mutagenic to Salmonella typhimurium TA100 strain without metabolic activation. The number of His+ revertant colonies was 1200/10-µmol eq of thiamine. Hence, thiamine is an undesirable precursor of DNA strand breakage and mutagenic substance (s) when mixed with nitrite. © 1995, The Pharmaceutical Society of Japan. All rights reserved.

Cite

CITATION STYLE

APA

Hiramoto, K., Ni-iyama, H., Kato, T., & Kikugawa, K. (1995). Thiamine Is a Precursor of DNA Strand Breakage and Mutagenic Substance (s) When Mixed with Nitrite. Japanese Journal of Toxicology and Environmental Health, 41(6), 447–451. https://doi.org/10.1248/jhs1956.41.447

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free