Soy Hydrolysate Optimization for Cell Culture Applications

Abstract

Soy hydrolysates often provide significant performance enhancements to the serum-free cultivation of mammalian cells and are frequently used in the biomanufacturing industry. However, historically there have been concerns with variability in performance which could directly impact cell culture protein titers. Given the critical nature of soy hydrolysates in the production of biotherapeutic proteins, there is value in understanding what parameters in the manufacture of soy hydrolysates have significant impact on cell culture performance. By modifying and/or better controlling these critical hydrolysate manufacturing parameters, it may be possible to significantly reduce variability, as well as optimize performance.