Neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are well-recognized symptoms although the pathophysiology of neuropsychiatric SLE (NPSLE) is unclear. Since an association with antiphospholipid antibodies has been reported, we examined the prevalence of antiphosphatidylserine-prothrombin antibodies (anti-PS/PT Abs), lupus anticoagulant (LA), anticardiolipin/ β2-glycoprotein I antibodies (anti-β2-GPI Abs), and antiribosomal P protein antibodies (antiribosomal P Abs) in 68 SLE patients and analyzed their associations with neuropsychiatric manifestations. The prevalence of LA was significantly higher in the patients with neuropsychiatric (NP) features than those without NP features (P<0.02). The levels of anti-PS/PT antibody were also significantly higher in the patients with NP features than those without NP features (P<0.01). The results indicate that LA positivity and higher levels of anti-PS/PT antibody can be predictive markers for NPSLE. © Clinical Rheumatology 2009.
CITATION STYLE
Syuto, T., Shimizu, A., Takeuchi, Y., Tanaka, S., Hasegawa, M., Nagai, Y., … Ishikawa, O. (2009). Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus. Clinical Rheumatology, 28(7), 841–845. https://doi.org/10.1007/s10067-009-1123-1
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