Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei

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Abstract

In our ongoing search for new pharmacologically active leads from Solomon organisms, we have examined the sponge Theonella swinhoei. Herein we report the isolation and structure elucidation of swinholide A (1) and one new macrolide, swinholide J (2). Swinholide J is an unprecedented asymmetric 44-membered dilactone with an epoxide functionality in half of the molecule. The structural determination was based on extensive interpretation of high-field NMR spectra and HRESIMS data. Swinholide J displayed potent in vitro cytotoxicity against KB cells (human nasopharynx cancer) with an IC50 value of 6 nM. © 2011 by the authors.

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De Marino, S., Festa, C., D’Auria, M. V., Cresteil, T., Debitus, C., & Zampella, A. (2011). Swinholide J, a potent cytotoxin from the marine sponge Theonella swinhoei. Marine Drugs, 9(6), 1133–1141. https://doi.org/10.3390/md9061133

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