Clinical Laboratory Features of Microbes That Cause Neonatal Sepsis: An 8-Year Retrospective Study

3Citations
Citations of this article
30Readers
Mendeley users who have this article in their library.

Abstract

Purpose: To determine the distribution and antibiotic resistance patterns among pathogens that cause neonatal sepsis (NS) and to assess trends in antibiotic resistance. Patients and methods: A total of 864 patients with sepsis admitted to a neonatal intensive care unit (NICU) between 2014 and 2021 were enrolled. Data on neonate age and sex, pathogenic microbes, and antimicrobial susceptibility were collected. Univariate and linear regression analyses were performed to determine the differences and trends in antibiotic resistance rates. Results: The overall incidence rate of NS was 4.59 cases per 1000 live births. Of these cases, 255 (29.5%) were early-onset neonatal sepsis (EONS) and 609 (70.5%) were late-onset neonatal sepsis (LONS). A total of 670 (70.5%) gram-positive cocci and 171 (19.8%) gram-negative bacilli were identified. Among the 552 coagulase-negative Staphylococcus (CoNS) strains, the rate of oxacillin resistance was 70.6%, but no strains were resistant to linezolid, vancomycin or tigecycline. Among the antibiotic resistance patterns of the top three gram-negative pathogens, K. pneumoniae showed the highest rates of resistance, with resistance rates of 37.9% and 39.4% to ertapenem and imipenem, respectively, while E. coli and Enterobacter cloacae showed high levels of susceptibility to both. With regard to the trends in resistance among important pathogens, the rates of resistance to rifampicin, ciprofloxacin, levofloxacin, moxifloxacin and clindamycin by Staphylococcus epidermidis significantly decreased (p<0.05) during the study period. E. coli strains exhibited a significant increase in ceftriaxone resistance during the study period (p<0.05). Conclusion: CoNS was the main microbe that caused NS, followed by E. coli. The bacterial isolates showed varying levels of resistance to the antimicrobial drugs tested. Thus, periodic surveillance in hospital settings to monitor changes in pathogens and antibiotic resistance is important.

References Powered by Scopus

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

4068Citations
N/AReaders
Get full text

Neonatal sepsis

839Citations
N/AReaders
Get full text

Early-onset neonatal sepsis

706Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Risk Factors Associated with Multi-Drug Resistance in Neonatal Sepsis Caused by Escherichia coli

10Citations
N/AReaders
Get full text

Factors Associated With Culture-proven Neonatal Sepsis and Resistance to First-line Antibiotics in Indonesia

3Citations
N/AReaders
Get full text

Oxacillin-resistant Staphylococcus spp.: Impacts on fatality in a NICU in Brazil - confronting the perfect storm

1Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Jin, Z., Wang, Z., Li, J., Yi, L., Liu, N., & Luo, L. (2022). Clinical Laboratory Features of Microbes That Cause Neonatal Sepsis: An 8-Year Retrospective Study. Infection and Drug Resistance, 15, 2983–2993. https://doi.org/10.2147/IDR.S367068

Readers' Seniority

Tooltip

Researcher 3

60%

Professor / Associate Prof. 1

20%

PhD / Post grad / Masters / Doc 1

20%

Readers' Discipline

Tooltip

Medicine and Dentistry 3

43%

Biochemistry, Genetics and Molecular Bi... 2

29%

Pharmacology, Toxicology and Pharmaceut... 1

14%

Engineering 1

14%

Save time finding and organizing research with Mendeley

Sign up for free