Erythrocytes are readily available cells and a good model system to study the health status of individuals with pathologic complications. It can also serve as a meaningful target to study toxicant/xenobioticinduced damages. We have prepared different concentrations of a carbamate pesticide (carbofuran) and carried out experiments to determine its toxicity on erythrocytes in terms of mean erythrocyte fragility (MEF). We observed a significant alteration in the osmotic fragility upon treatment with carbofuran. In our earlier studies we have observed a good correlation between OF and OS in diabetic subjects. Study reveals OF as a potential biomarker of oxidative membrane damage in pathologic conditions as well as toxicant/xenobiotic/pesticide-induced oxidative membrane damage to erythrocytes. © 2010 Humana Press, a part of Springer Science + Business Media, LLC.
CITATION STYLE
Sharma, B., Rai, D. K., Rai, P. K., Rizvi, S. I., & Watal, G. (2010). Determination of erythrocyte fragility as a marker of pesticide-induced membrane oxidative damage. Methods in Molecular Biology, 594, 123–128. https://doi.org/10.1007/978-1-60761-411-1_8
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