Despite timely intervention, there exists a small subgroup of patients with septic shock who develop progressive multi-organ failure. Seemingly refractory to conventional therapy, they exhibit a very high mortality. Such patients are often poorly represented in large clinical trials. Consequently, good evidence for effective treatment strategies is lacking. In this article, we describe a pragmatic, multi-faceted approach to managing patients with refractory septic shock based on our experience of toxin-mediated sepsis in a specialist referral centre. Many components of this strategy are inexpensive and widely accessible, and so may offer an opportunity to improve outcomes in these critically ill patients.
CITATION STYLE
Nandhabalan, P., Ioannou, N., Meadows, C., & Wyncoll, D. (2018, September 19). Refractory septic shock: our pragmatic approach. Critical Care. BioMed Central Ltd. https://doi.org/10.1186/s13054-018-2144-4
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