Role of insulin-sensitizing drugs in PCOS management

0Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.
Get full text

Abstract

Although the role of insulin resistance in the pathogenesis of polycystic ovary syndrome is now well established, confusion exists in common daily practice regarding the role of insulin-sensitizing drugs (ISDs) in the management of this condition. This chapter is an attempt to formulate practice points on the value of ISDs in improving pregnancy outcomes, ameliorating androgen excess symptoms, and modifying metabolic risks in view of available evidence. Clearly, there is a lack of high-quality evidence about effectiveness at all identified outcome endpoints. Moderate-quality evidence indicates a beneficial role for metformin monotherapy in the reproductive management of nonobese women (BMI <30 kg/m2) with PCOS-related subfertility, and a similar role for metformin co-therapy in combination with clomiphene citrate in the obese (BMI ≥30 kg/m2). An effective role for metformin/clomiphene combination therapy has also been established on the basis of low-quality evidence in CC-resistant women. Metformin co-treatment has not shown to improve clinical pregnancies, miscarriages, or live births when used during assisted reproductive technology cycles, but has been shown to reduce the risk of ovarian hyperstimulation syndrome. Evidence implying a role for metformin in ameliorating symptoms of androgen excess, namely, hirsutism and acne, is of poor quality. While benefits are implied, data supporting a role for metformin therapy in reducing the incidence of type 2 diabetes mellitus, coronary artery disease, or endometrial cancer in women with PCOS are nonexistent.

Cite

CITATION STYLE

APA

Awwad, J. T., & Ghazeeri, G. (2014). Role of insulin-sensitizing drugs in PCOS management. In Polycystic Ovary Syndrome: Current and Emerging Concepts (Vol. 9781461483946, pp. 165–180). Springer New York. https://doi.org/10.1007/978-1-4614-8394-6_10

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free