Bone marrow and adipose tissue adenosine receptors effect on osteogenesis and adipogenesis

20Citations
Citations of this article
18Readers
Mendeley users who have this article in their library.

Abstract

Adenosine is an extracellular signaling molecule that is particularly relevant in times of cellular stress, inflammation and metabolic disturbances when the levels of the purine increase. Adenosine acts on two G-protein-coupled stimulatory and on two G-protein-coupled inhibitory receptors, which have varying expression profiles in different tissues and conditions, and have different affinities for the endogenous ligand. Studies point to significant roles of adenosine and its receptors in metabolic disease and bone health, implicating the receptors as potential therapeutic targets. This review will highlight our current understanding of the dichotomous effects of adenosine and its receptors on adipogenesis versus osteogenesis within the bone marrow to maintain bone health, as well as its relationship to obesity. Therapeutic implications will also be reviewed.

Cite

CITATION STYLE

APA

Eisenstein, A., Chitalia, S. V., & Ravid, K. (2020, October 2). Bone marrow and adipose tissue adenosine receptors effect on osteogenesis and adipogenesis. International Journal of Molecular Sciences. MDPI AG. https://doi.org/10.3390/ijms21207470

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free