Correlation of serum lipid profile with leptin levels of skin tags patients

Abstract

Skin tags may be associated with increased adipose deposition. Mechanism of skin tags formation is through the activation of leptin receptor in the dermis and epidermis. Recent study suggested that the presence of skin tags is associated with obesity, abnormal lipid profile and elevated serum leptin levels. Researcher are interested to analyse the correlation betwen serum lipid profile and leptin levels of patients with skin tags. This is a cross sectional study, conducted from October 2017 to February 2018 at Tumor and Dermatosurgery Divison-Dermatology and Venereology Department outpatient clinic in Dr. Mohammad Hoesin General Hospital Palembang. Sample study was obtained with consecutive sampling. There were 40 patients with skin tags that met the inclusion criteria included in the study. Serum lipid profile and serum leptin were measured. Statistic significant correlation between triglycerides and leptin levels was found (p=0.04; r=0.327), however there was no significant correlation between total cholesterol, LDL, HDL cholesterol with leptin levels (p=0.273; r=0.177, p=0.288; r=0.172, p=0.794; r=0.043). Triglyceride levels was found to have significant correlation with leptin levels.